溶剂环境对多肽旋光色散参数的影响。I. 聚-γ-苄基-L-谷氨酸的研究。
The effects of solvent environment on the optical rotatory dispersion parameters of polypeptides. I. Studies on poly-gamma-benzyl-L-glutamate.
作者信息
Cassim J Y, Taylor E W
出版信息
Biophys J. 1965 Jul;5(4):553-71. doi: 10.1016/S0006-3495(65)86734-0.
Abstract
The constancy of the Moffitt optical rotatory dispersion parameters for polypeptides in different solvents was tested by dispersion measurements on poly-gamma-benzyl-L-glutamate in fifty-five solvents and solvent mixtures. b(0) was not constant but varied linearly with the refractive index of the solvent according to the equation -b(0) = 1701 - 730.3 n(8). This variation could not be explained by changes in configuration of the polypeptide. a(0) also showed a trend with solvent index but the values were widely scattered. lambda(0) did not show a statistically significant dependence on solvent index. The variation in b(0) can be interpreted as an effect of solvent polarizability on the frequencies of optically active transitions.
摘要
通过对聚-γ-苄基-L-谷氨酸在55种溶剂和溶剂混合物中的色散测量，测试了莫菲特（Moffitt）旋光色散参数在不同溶剂中对多肽的恒定性。b(0)并非恒定不变，而是根据方程-b(0) = 1701 - 730.3 n(8)随溶剂折射率呈线性变化。这种变化无法用多肽构型的改变来解释。a(0)也随溶剂指数呈现出一种趋势，但数值分布广泛。λ(0)对溶剂指数没有显示出统计学上的显著依赖性。b(0)的变化可以解释为溶剂极化率对旋光跃迁频率的影响。
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