Köhler G K, Krankenhagen B, Westphal K
Fortschr Neurol Psychiatr Grenzgeb. 1977 May;45(5):293-305.
392 cases of cerebrovascular disturbances in women while taking oral contraceptives are reported since 1962. There has been a remarkable change of the distribution of age among these women. Till 1970 were mostly women involved between the age of 30 and 34 years. Today this type of distribution is no more to be seen because of the growing number of reports about complications in other age-groups. Complications were till 1970 mostly reported in the period from ten days till six months after taking oral contraceptives. The publications of the last three years are showing that many women are involved, who had taken oral contraceptives more than two years. New publications and our own results are showing no changes of the clinical syndromes and of the prognosis. Our investigation shows no decrease in the number of young women suffering of thromboembolic cerebral disorders of unknown aetiology in the last years. In this group is the percentage of the women, which had taken ovulation inhibitors, no reduced. The conception, that there is a connection between oral contraceptives and cerebrovascular occlusions seems more possible as before. Especially attention in prescription of oral contraceptives should be given to the fact of a known predisposition. The rareness of these complications leads to the conclusion that one or more predisponating factors of a nature not yet known have to be existent.
自1962年以来，共报告了392例女性在服用口服避孕药期间出现脑血管疾病的病例。这些女性的年龄分布发生了显著变化。直到1970年，大多数病例涉及年龄在30至34岁之间的女性。如今，由于其他年龄组并发症报告数量的增加，这种年龄分布类型已不复存在。1970年以前，并发症大多在服用口服避孕药后10天至6个月期间报告。过去三年的出版物表明，许多服用口服避孕药超过两年的女性也出现了并发症。新的出版物和我们自己的研究结果表明，临床综合征和预后没有变化。我们的调查显示，近年来病因不明的血栓栓塞性脑疾病的年轻女性患者数量没有减少。在这组患者中，服用排卵抑制剂的女性比例没有降低。口服避孕药与脑血管闭塞之间存在关联的观念似乎比以往任何时候都更有可能。在开具口服避孕药处方时，尤其应注意已知的易患因素。这些并发症的罕见性表明，必定存在一个或多个尚未知晓的易患因素。
