正常和低钠溶液中单个肌纤维的最大去极化速率。
Maximum rate of depolarization of single muscle fiber in normal and low sodium solutions.
作者信息
Ferroni A, Blanchi D
出版信息
J Gen Physiol. 1965 Sep;49(1):17-25. doi: 10.1085/jgp.49.1.17.
Abstract
The values of membrane action potentials and maximum depolarization rates of single muscle fibers in normal Tyrode solution and in low sodium solutions containing as little as 20 per cent of the sodium chloride were measured with intracellular microelectrodes. Under these conditions the membrane potential remains unchanged up to 36 per cent of Na(+) concentration, whereas the overshoot of the action potential varies linearly with the logarithm of the external sodium concentration. The maximum depolarization rate is a linear function of the external sodium concentration. The results obtained support the ionic theory for sodium and the independence principle for sodium current related to the external sodium concentration.
摘要
用细胞内微电极测量了正常台氏液以及含低至20%氯化钠的低钠溶液中单个肌纤维的膜动作电位值和最大去极化速率。在这些条件下，膜电位在细胞外[Na⁺]浓度达到36%之前保持不变，而动作电位的超射值则随细胞外钠浓度的对数呈线性变化。最大去极化速率是细胞外钠浓度的线性函数。所得结果支持钠的离子学说以及与细胞外钠浓度相关的钠电流独立性原理。
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