乙二醛对经胍化试剂和蛋白酶预处理的水疱性口炎病毒的杀病毒活性降低。
Diminished virucidal activity of kethoxal against vesicular stomatitis virus pretreated with guanidinating reagent and proteases.
作者信息
Sabina L R, Morrow D G, Szabo R A
出版信息
Acta Virol. 1976 Apr;20(2):119-25.
PMID:5866
Abstract
The reactivity of vesicular stomatitis virus (VSV) with kethoxal can be appreciably altered by treatment with 1-guanyl-3, 5-dimethyl pyrazole nitrate (GDMP) and proteolytic enzymes. Pretreatment of purified VSV with GDMP or proteolytic enzymes markedly reduced the effectiveness of kethoxal as a virucide. The rate of neutralizability of GDMP- and trypsin-treated viruses by specific antiserum differed from that of controls.
摘要
水泡性口炎病毒（VSV）与乙二醛的反应性可通过用1-鸟嘌呤基-3,5-二甲基吡唑硝酸盐（GDMP）和蛋白水解酶处理而明显改变。用GDMP或蛋白水解酶对纯化的VSV进行预处理，可显著降低乙二醛作为杀病毒剂的效力。经GDMP和胰蛋白酶处理的病毒被特异性抗血清中和的速率与对照不同。
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