Peckham M J, McElwain T J
Clin Endocrinol Metab. 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1.
With modern methods of diagnosis, staging and treatment, seminoma is a highly curable tumour. The worse results for the treatment of teratomas are likely to improve particularly as methods for detection of the tumour improve and as types of treatment are increasingly combined in a way which takes account of the biology of the tumour and the strength and limitation of each treatment modality. Stage I and II teratoma should receive irradiation after orchidectomy although when bulky retroperitoneal disease is present irradiation alone is rarely capable of securing local tumour control. In these cases chemotherapy may achieve nodal regression preparatory to irradiation. Excision of residual masses after irradiation should be considered in teratoma. Chemotherapy is the treatment of choice for disseminated teratoma but maintaining tumour control poses problems. Whole lung irradiation following chemotherapy is being assessed in selected patients.
采用现代诊断、分期和治疗方法,精原细胞瘤是一种治愈率很高的肿瘤。畸胎瘤的治疗效果较差,但随着肿瘤检测方法的改进以及治疗方式越来越多地根据肿瘤生物学特性和每种治疗方式的优势与局限性进行联合应用,其治疗效果可能会得到改善。Ⅰ期和Ⅱ期畸胎瘤在睾丸切除术后应接受放疗,不过当存在巨大腹膜后病变时,单纯放疗很少能够确保局部肿瘤得到控制。在这些情况下,化疗可使淋巴结缩小,为放疗做准备。畸胎瘤患者在放疗后应考虑切除残留肿块。化疗是播散性畸胎瘤的首选治疗方法,但维持肿瘤控制存在问题。目前正在对部分患者评估化疗后进行全肺照射的效果。