Sapozhkov A V
Farmakol Toksikol. 1975 Mar-Apr;38(2):177-80.
In acute experiments staged on dogs subject to investigation was collateral coronary circulation studied by registering the retrograde blood flow and the pressure in the ligated coronary artery. It is shown that atropinization (0.05 mg/kg) does not change the positive action of papaverine and diethyphen (2 mg/kg) on the inflow of blood into the area of myocardial ischemia and enhances the beneficial effect on euphylline (4 mg/kg). Preliminary introduction of octadine (5 mg/kg) had no material influence on the nature of the diethyphen action, but greatly weakened that of euphylline and reduced the effect of papaverine. The vasodilating agents attenuated for a short while a pituitrin-induced (0.5 U/kg) spasm of the collaterals and vessels in the ischemic area of the myocardium.
在对狗进行的急性实验中，通过记录结扎冠状动脉的逆行血流和压力来研究冠状动脉侧支循环。结果表明，阿托品化（0.05毫克/千克）不会改变罂粟碱和二乙酚（2毫克/千克）对心肌缺血区域血液流入的积极作用，且会增强对氨茶碱（4毫克/千克）的有益作用。预先注射奥他定（5毫克/千克）对二乙酚的作用性质没有实质性影响，但大大削弱了氨茶碱的作用，并降低了罂粟碱的效果。血管扩张剂在短时间内减轻了垂体后叶素诱导（0.5单位/千克）的心肌缺血区域侧支血管和血管痉挛。
