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K5 values of some homologous series of barbiturates and the relationship with the lipophilicity and metabolic clearance.

作者信息

Yih T D, van Rossum J M

出版信息

Biochem Pharmacol. 1977 Nov 15;26(22):2117-20. doi: 10.1016/0006-2952(77)90261-1.

DOI:10.1016/0006-2952(77)90261-1
PMID:588293
Abstract
摘要

相似文献

1
K5 values of some homologous series of barbiturates and the relationship with the lipophilicity and metabolic clearance.一些巴比妥酸盐同系物的K5值及其与亲脂性和代谢清除率的关系。
Biochem Pharmacol. 1977 Nov 15;26(22):2117-20. doi: 10.1016/0006-2952(77)90261-1.
2
Pharmacokinetics of some homologous series of barbiturates in the intact rat and in the isolated perfused rat liver.
J Pharmacol Exp Ther. 1977 Oct;203(1):184-92.
3
Effect of lipid solubility and dose on the elimination of barbiturates in rabbits.脂溶性和剂量对家兔巴比妥类药物消除的影响。
Chem Pharm Bull (Tokyo). 1979 Jul;27(7):1501-9. doi: 10.1248/cpb.27.1501.
4
QSAR in drug metabolism and disposition. An application to the affinity for cytochrome P-450 and hepatic clearance of barbiturates.药物代谢与处置中的定量构效关系。其在巴比妥类药物对细胞色素P-450的亲和力及肝脏清除率方面的应用。
Pharm Acta Helv. 1978;53(5):143-6.
5
Dependence of hydrogen peroxide formation in rat liver microsomes on the molecular structure of cytochrome P-450 substrates: a study with barbiturates and beta-adrenoceptor antagonists.大鼠肝微粒体中过氧化氢生成对细胞色素P-450底物分子结构的依赖性：巴比妥类药物和β-肾上腺素能受体拮抗剂的研究
Eur J Drug Metab Pharmacokinet. 1989 Apr-Jun;14(2):93-100. doi: 10.1007/BF03190847.
6
Relationship between lipophilicity and hepatic dispersion and distribution for a homologous series of barbiturates in the isolated perfused in situ rat liver.巴比妥类同系物在原位灌注大鼠肝脏中的亲脂性与肝分散及分布的关系。
Drug Metab Dispos. 1993 Sep-Oct;21(5):933-8.
7
Binding of barbiturates to hepatic microsomes of the rat.巴比妥类药物与大鼠肝脏微粒体的结合。
Biochem Pharmacol. 1977 May 15;26(10):988-91. doi: 10.1016/0006-2952(77)90481-6.
8
Lipoperoxidation of rat liver microsomal lipids induced by carbon tetrachloride.四氯化碳诱导的大鼠肝微粒体脂质过氧化作用。
Nature. 1966 Jun 11;210(5041):1162-3. doi: 10.1038/2101162a0.
9
Prediction of in vivo tissue distribution from in vitro data. 3. Correlation between in vitro and in vivo tissue distribution of a homologous series of nine 5-n-alkyl-5-ethyl barbituric acids.根据体外数据预测体内组织分布。3. 9种5 - n -烷基 - 5 -乙基巴比妥酸同系物的体外与体内组织分布之间的相关性。
Pharm Res. 2003 Jun;20(6):864-72. doi: 10.1023/a:1023912318133.
10
The rate of N-demethylation of N,N-dimethylanilines and N-methylanilines by rat-liver microsomes is related to their first ionization potential, their lipophilicity and to a steric bulk factor.大鼠肝脏微粒体对N,N-二甲基苯胺和N-甲基苯胺的N-去甲基化速率与它们的第一电离电位、亲脂性以及一个空间位阻因子有关。
Xenobiotica. 1986 Jun;16(6):511-7. doi: 10.3109/00498258609043539.

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Relationship of octanol/water partition coefficient and molecular weight to cellular permeability and partitioning in s49 lymphoma cells.辛醇/水分配系数和分子量与 S49 淋巴瘤细胞的细胞通透性和分配的关系。
Pharm Res. 1984 Nov;1(6):259-66. doi: 10.1023/A:1016393902123.
2
Prediction of in vivo tissue distribution from in vitro data. 3. Correlation between in vitro and in vivo tissue distribution of a homologous series of nine 5-n-alkyl-5-ethyl barbituric acids.根据体外数据预测体内组织分布。3. 9种5 - n -烷基 - 5 -乙基巴比妥酸同系物的体外与体内组织分布之间的相关性。
Pharm Res. 2003 Jun;20(6):864-72. doi: 10.1023/a:1023912318133.
3
Prediction of hepatic first-pass metabolism and plasma levels following intravenous and oral administration of barbiturates in the rabbit based on quantitative structure-pharmacokinetic relationships.
基于定量构效关系预测巴比妥类药物静脉注射和口服给药后家兔的肝首过代谢及血浆水平。
J Pharmacokinet Biopharm. 1988 Jun;16(3):279-301. doi: 10.1007/BF01062138.
4
Liposomes as carriers of poorly water-soluble substrates: linear modelling of membrane systems with catalytic or binding sites of different facedness. Significance of experimental membrane partition coefficients and of kinetic and equilibrium parameters.脂质体作为难溶性底物的载体：具有不同朝向催化或结合位点的膜系统的线性建模。实验性膜分配系数以及动力学和平衡参数的意义。
Biochem J. 1988 Aug 15;254(1):101-8. doi: 10.1042/bj2540101.
5
Dependence of hydrogen peroxide formation in rat liver microsomes on the molecular structure of cytochrome P-450 substrates: a study with barbiturates and beta-adrenoceptor antagonists.大鼠肝微粒体中过氧化氢生成对细胞色素P-450底物分子结构的依赖性：巴比妥类药物和β-肾上腺素能受体拮抗剂的研究
Eur J Drug Metab Pharmacokinet. 1989 Apr-Jun;14(2):93-100. doi: 10.1007/BF03190847.
6
Relative potencies for barbiturate binding to the Torpedo acetylcholine receptor.巴比妥酸盐与电鳐乙酰胆碱受体结合的相对效价。
Br J Pharmacol. 1990 Nov;101(3):710-4. doi: 10.1111/j.1476-5381.1990.tb14145.x.
7
Interaction of 7-n-alkoxycoumarins with cytochrome P-450(2) and their partitioning into liposomal membranes. Assessment of methods for determination of membrane partition coefficients.7-正烷氧基香豆素与细胞色素P-450(2)的相互作用及其在脂质体膜中的分配。膜分配系数测定方法的评估。
Biochem J. 1992 Jun 1;284 ( Pt 2)(Pt 2):483-90. doi: 10.1042/bj2840483.