不同表位密度的二硝基苯基-左聚糖缀合物的体外免疫原性、耐受性和促有丝分裂性比较。
Comparison of in vitro immunogenicity, tolerogenicity and mitogenicity of dinitrophenyl-levan conjugates with varying epitope density.
作者信息
Desaymard C, Ivanyi L
出版信息
Immunology. 1976 May;30(5):647-53.
Abstract
The mitogenicity, immunogenicity and tolerogenicity of various DNP-levan (DNP-LE) conjugates were compared using in vitro methods. Anti-DNP antibody synthesis induced by DNP-LE conjugates was related to the epitope density of DNP, BUT WAS NOT AFFECTED BY Macrophage dependent and was not influenced by the degree of hapten conjugation. These results imply that mitogenicity of an antigen is not necessarily related to the specific triggering of B cells.
摘要
使用体外方法比较了各种二硝基苯-左聚糖（DNP-LE）缀合物的促有丝分裂性、免疫原性和耐受性。DNP-LE缀合物诱导的抗DNP抗体合成与DNP的表位密度有关，但不受巨噬细胞依赖性影响，也不受半抗原缀合程度的影响。这些结果表明，抗原的促有丝分裂性不一定与B细胞的特异性触发有关。
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