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长期卵巢切除术后大鼠正中隆起多巴胺含量的增加及其雌激素替代的逆转作用。

Increase in dopamine content of the rat median eminence after long-term ovariectomy and its reversal by estrogen replacement.

作者信息

Gudelsky G A, Annunziato L, Moore K E

出版信息

Endocrinology. 1977 Dec;101(6):1894-7. doi: 10.1210/endo-101-6-1894.

DOI:10.1210/endo-101-6-1894
PMID:588327
Abstract

The norepinephrine (NE) and dopamine (DA) concentrations of the median eminence and the remaining hypothalamus of female rats were assayed using a sensitive radioenzymatic method. There were no changes in the catecholamine concentrations of either brain region when measured in the mornings of the different days of the estrous cycle. Four to 5 weeks after ovariectomy there was a marked increase in the DA but not the NE content of the median eminence, and the daily administration of estradiol benzoate for 7 days prior to sacrifice reversed the ovariectomy-induced increase in DA. Ovariectomy did not alter catecholamine concentrations in the remaining hypothalamus.

摘要

采用灵敏的放射酶法测定了雌性大鼠正中隆起和下丘脑其余部分的去甲肾上腺素(NE)和多巴胺(DA)浓度。在动情周期不同天数的上午进行测量时,两个脑区的儿茶酚胺浓度均无变化。卵巢切除术后4至5周,正中隆起的DA含量显著增加,但NE含量未增加,且在处死前连续7天每日给予苯甲酸雌二醇可逆转卵巢切除诱导的DA增加。卵巢切除术未改变下丘脑其余部分的儿茶酚胺浓度。

相似文献

1
Increase in dopamine content of the rat median eminence after long-term ovariectomy and its reversal by estrogen replacement.长期卵巢切除术后大鼠正中隆起多巴胺含量的增加及其雌激素替代的逆转作用。
Endocrinology. 1977 Dec;101(6):1894-7. doi: 10.1210/endo-101-6-1894.
2
Evidence that catecholaminergic and peptidergic (luteinizing hormone-releasing hormone) neurons in suprachiasmatic-medial preoptic, medial basal hypothalamus and median eminence are involved in estrogen-negative feedback.有证据表明,视交叉上核-内侧视前区、下丘脑内侧基底部和正中隆起中的儿茶酚胺能神经元和肽能(促黄体生成素释放激素)神经元参与雌激素负反馈。
Endocrinology. 1980 Oct;107(4):892-901. doi: 10.1210/endo-107-4-892.
3
Acute changes in norepinephrine content in the median eminence induced by orchidectomy or testosterone replacement.去势或睾酮替代诱导的正中隆起中去甲肾上腺素含量的急性变化。
Endocrinology. 1976 Aug;99(2):629-34. doi: 10.1210/endo-99-2-629.
4
The role of catecholamines in the regulation of gonadotropin secretion.儿茶酚胺在促性腺激素分泌调节中的作用。
Acta Morphol Hung. 1983;31(1-3):101-15.
5
Attenuation during aging of the postovariectomy rise in median eminence catecholamines.
Neuroendocrinology. 1981 Sep;33(3):144-7. doi: 10.1159/000123219.
6
Negative feedback effects of progesterone correlated with changes in hypothalamic norepinephrine and dopamine turnover rates, median eminence luteinizing hormone-releasing hormone, and peripheral plasma gonadotropins.孕酮的负反馈作用与下丘脑去甲肾上腺素和多巴胺周转率、正中隆起促黄体生成激素释放激素以及外周血浆促性腺激素的变化相关。
Endocrinology. 1981 Jun;108(6):2194-9. doi: 10.1210/endo-108-6-2194.
7
Catecholamine turnover rates in discrete hypothalamic areas and associated changes in median eminence luteinizing hormone-releasing hormone and serum gonadotropins on proestrus and diestrous day 1.发情前期和动情期第1天,下丘脑不同区域的儿茶酚胺周转率以及正中隆起促黄体生成素释放激素和血清促性腺激素的相关变化。
Endocrinology. 1981 May;108(5):1795-802. doi: 10.1210/endo-108-5-1795.
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Inhibition of estrogen-induced anterior pituitary enlargement and arteriogenesis by bromocriptine in Fischer 344 rats.溴隐亭对Fischer 344大鼠雌激素诱导的垂体前叶增大和动脉生成的抑制作用。
Endocrinology. 1987 Feb;120(2):617-21. doi: 10.1210/endo-120-2-617.
9
Increase in medial palisade zone dopamine activity after long-term castration in the male rat.
Endokrinologie. 1980 Jul;76(1):23-8.
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The lateral and medial median eminence: distribution of dopamine, norepinephrine, and luteinizing hormone-releasing hormone and the effect of prolactin on catecholamine turnover.外侧和内侧正中隆起:多巴胺、去甲肾上腺素和促黄体生成激素释放激素的分布以及催乳素对儿茶酚胺代谢的影响。
Endocrinology. 1981 May;108(5):1716-22. doi: 10.1210/endo-108-5-1716.

引用本文的文献

1
Estrogen-dependent changes in the functional interrelationships among neurons, ependymal cells and glial cells of the arcuate nucleus. Cytometric studies in the female albino mouse.弓状核神经元、室管膜细胞和神经胶质细胞之间功能相互关系的雌激素依赖性变化。雌性白化小鼠的细胞计数研究。
Cell Tissue Res. 1982;227(1):113-28. doi: 10.1007/BF00206335.
2
Dopa accumulation is a measure of dopamine synthesis in the median eminence and posterior pituitary.多巴积累是中隆突和垂体后叶中多巴胺合成的一种度量。
J Neural Transm. 1979;46(3):183-93. doi: 10.1007/BF01250784.