Basta J W, Niejadlik K, Pallares V
Br J Anaesth. 1977 Nov;49(11):1087-91. doi: 10.1093/bja/49.11.1087.
Autonomic hyperreflexia (AH) is a clinical syndrome associated with the development of severe hypertension. It usually occurs in patients with high-level chronic spinal cord injury, and in response to stimuli associated with the distension of a hollow viscus. Protection against AH by the prophylactic use of pentolinium tartrate (Ansolysen) in doses of 10-15 mg was evaluated in a controlled study of unanaesthetized patients who were either quadriplegic or paraplegic and who were undergoing rectal and bladder surgical procedures. When compared with the control group, the systolic and diastolic arterial pressures during operation were significantly less (P less than 0.05) and remained near normal in the pretreated patients. The use of pentolinium to prevent or control AH during surgical procedures in patients with chronic spinal cord damage is a simple alternative to spinal or general anaesthesia.
自主神经反射亢进（AH）是一种与严重高血压发展相关的临床综合征。它通常发生在高位慢性脊髓损伤患者中，是对与中空脏器扩张相关刺激的反应。在一项针对四肢瘫痪或截瘫且正在接受直肠和膀胱外科手术的未麻醉患者的对照研究中，评估了预防性使用剂量为10 - 15毫克的酒石酸喷托铵（安血定）对AH的预防作用。与对照组相比，手术期间预处理患者的收缩压和舒张压显著更低（P小于0.05），且仍接近正常水平。在慢性脊髓损伤患者的外科手术过程中，使用喷托铵预防或控制AH是脊髓麻醉或全身麻醉的一种简单替代方法。
