Kirkaldy J S
Biophys J. 1965 Nov;5(6):981-6. doi: 10.1016/S0006-3495(65)86763-7.
The human brain may be regarded as an irreversible system which is constrained by a fixed inflow of free energy in the form of chemical nourishment from within the body and information from the environment. The evolution of the internal spontaneous process may be described as a path on the saddle surface of entropy production rate in the configuration space of the process variables. From any initial state of high entropy production the system evolves towards the saddle point by a series of regessions to temporary minima alternating with fluctuations which introduce new internal constraints and open new channels for regression. The spontaneous regression steps of the process are to be associated with the learning process and the deductive processes of thought since information is necessarily being stored, whereas the fluctuation or nucleation steps are to be associated with the inductive or creative part of the thought process. The state of consciousness is to be associated with the system undergoing regression. If, under certain boundary conditions, the system attains the stable saddle point, a state of unconsciousness is attained in which no change of state variables occurs in time. The stability of this state is indicated by its resistance to perturbation.
人类大脑可被视为一个不可逆系统,它受到来自身体内部以化学营养形式存在的自由能固定流入以及来自环境的信息的限制。内部自发过程的演化可被描述为在过程变量配置空间中熵产生率鞍面上的一条路径。从任何高熵产生的初始状态开始,系统通过一系列向临时最小值的回归与波动交替演化,波动引入新的内部约束并为回归开辟新通道。该过程的自发回归步骤与学习过程和思维的演绎过程相关联,因为信息必然被存储,而波动或成核步骤与思维过程的归纳或创造性部分相关联。意识状态与正在经历回归的系统相关联。如果在某些边界条件下,系统达到稳定的鞍点,就会达到一种无意识状态,此时状态变量不会随时间发生变化。这种状态的稳定性由其对扰动的抵抗力来表明。