Pepperell R J, McBain J C, Winstone S M, Smith M A, Brown J B
Br J Obstet Gynaecol. 1977 Dec;84(12):898-903. doi: 10.1111/j.1471-0528.1977.tb12518.x.
Serum and prolactin levels and urinary oestrogen and pregnanediol excretion were measured during early pregnancy in 12 hyperprolactinaemic subjects who became pregnant during treatment with bromocriptine. Prolactin levels were suppressed below normal whilst taking the bromocriptine, but rose significantly when this drug was stopped and by eight weeks of gestation reached values significantly higher than those observed in normal pregnancy. Further increases in prolactin levels were, however, not observed. Urinary oestrogen and pregnanediol excretion was initially normal but, following cessation of bromocriptine, urinary pregnanediol excretion decreased and was significantly less than normal at 11 to 14 weeks gestation. These results suggest that elevated prolactin levels affect corpus luteum function of early pregnancy. Because the effect is maintained until at least 14 weeks gestation, prolactin may also affect progesterone production by the placenta.
对12名高催乳素血症患者在接受溴隐亭治疗期间怀孕后的孕早期血清催乳素水平以及尿雌激素和孕二醇排泄情况进行了测定。服用溴隐亭期间催乳素水平被抑制至正常水平以下，但停药后显著升高，至妊娠8周时达到显著高于正常妊娠时观察到的值。不过，催乳素水平并未进一步升高。尿雌激素和孕二醇排泄最初正常，但在溴隐亭停药后，尿孕二醇排泄减少，在妊娠11至14周时显著低于正常水平。这些结果表明，升高的催乳素水平会影响孕早期黄体功能。由于这种影响至少持续到妊娠14周，催乳素可能也会影响胎盘的孕酮生成。
