大脑中的组胺H2受体与可乐定产生的睡眠。
Histamine H2-receptors in the brain and sleep produced by clonidine.
作者信息
Vogt M
出版信息
Br J Pharmacol. 1977 Nov;61(3):441-3. doi: 10.1111/j.1476-5381.1977.tb08438.x.
Abstract
Sleep was induced in chicks aged 4-7 days by intravenous injection of clonidine hydrochloride 0.04 mumol/kg. Sleep was not prevented or altered by a preceding intramuscular injection of blockers of histamine H2-receptors which were used in doses (as mumol/kg) of up to 800 (metiamide) and 2400 (cimetidine). Clonidine, therefore, does not cause sleep by stimulating H2-receptors in the brain. The highest dose of cimetidine used had a hypnotic action of its own.
摘要
通过静脉注射0.04微摩尔/千克的盐酸可乐定诱导4至7日龄雏鸡睡眠。预先肌肉注射组胺H2受体阻滞剂（剂量高达800微摩尔/千克的甲硫咪胺和2400微摩尔/千克的西咪替丁）不会阻止或改变睡眠。因此，可乐定不是通过刺激大脑中的H2受体来引起睡眠的。所使用的最高剂量的西咪替丁自身具有催眠作用。
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本文引用的文献
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Sleep produced by clonidine (2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride).
Br J Pharmacol. 1971 Dec;43(4):685-95. doi: 10.1111/j.1476-5381.1971.tb07203.x.
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Possible involvement of central histamine H2-receptors in the hypotensive effect of clonidine.中枢组胺H2受体可能参与可乐定的降压作用。
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No evidence for central histamine-receptor involvement with the hypotensive effect of clonidine in cats.没有证据表明中枢组胺受体参与可乐定对猫的降压作用。
Eur J Pharmacol. 1976 Dec;40(2):365-8. doi: 10.1016/0014-2999(76)90075-3.
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Further evidence for central histamine H2-receptor involvement in the hypotensive effect of clonidine in the rat.关于中枢组胺H2受体参与可乐定对大鼠降压作用的进一步证据。
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Evidence that clonidine can activate histamine H2-receptors in rat cerebral cortex.可乐定可激活大鼠大脑皮层组胺H2受体的证据。
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Stimulation of cerebral histamine H2 receptors by clonidine.可乐定对脑组胺H2受体的刺激作用。
Nature. 1976 Jul 22;262(5566):307-8. doi: 10.1038/262307a0.
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