凝血酶-纤维蛋白原反应缺陷所致去纤维蛋白综合征，可被鱼精蛋白逆转。
Defibrination syndrome with defective thrombinfibrinogen reaction reversible by protamine.
作者信息
Bloom A L, Campbell N
出版信息
J Clin Pathol. 1965 Nov;18(6):786-9. doi: 10.1136/jcp.18.6.786.
Abstract
A patient with the obstetric defibrination syndrome successfully treated with human fibrinogen is described. The blood not only contained low levels of fibrinogen capable of clotting but also contained an inhibitor of the thrombin-fibrinogen reaction. This was neutralized in vitro with protamine but it was not heparin. Neither abnormality was detected by a latex agglutination test for plasma fibrinogen. The use of this test does not therefore exclude the diagnosis of the defibrination syndrome.
摘要
本文描述了一名患有产科去纤维蛋白综合征的患者，经人纤维蛋白原成功治疗。该患者血液中不仅含有低水平的可凝血纤维蛋白原，还含有凝血酶-纤维蛋白原反应的抑制剂。该抑制剂在体外能用鱼精蛋白中和，但不是肝素。血浆纤维蛋白原的乳胶凝集试验未检测到任何异常。因此，该试验的应用并不能排除去纤维蛋白综合征的诊断。
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