Moukhtar M, Aleem F A, Hung H C, Sommers S C, Klinger H P, Romney S L
Cancer. 1977 Dec;40(6):2957-66. doi: 10.1002/1097-0142(197712)40:6<2957::aid-cncr2820400631>3.0.co;2-m.
A 22 year-old phenotypic female with a 45,x/46,x, r(x) mosaic complement had anovulatory cycles, histologically normal ovaries, and atypical endometrial hyperplasia which, when clinically followed by repeated biopsies, was found to progress to locally invasive endometrial carcinoma. This was successfully managed by the induction of ovulation with Clomid, which resulted in conversion of the endometrium to a normal secretory pattern for two subsequent years.
一名22岁的表型女性，其染色体组成为45,x/46,x,r(x)嵌合体，出现无排卵周期，卵巢组织学正常，但有非典型子宫内膜增生，在临床随访中经多次活检发现其进展为局部浸润性子宫内膜癌。通过使用克罗米酚诱导排卵成功处理了该情况，随后两年子宫内膜转变为正常分泌型。
