Busuttil A
Clin Otolaryngol Allied Sci. 1977 Aug;2(3):199-206. doi: 10.1111/j.1365-2273.1977.tb01358.x.
Salivary tissue shows inflammatory changes, atrophy, replacement fibrosis, marked pleomorphism and atypia of the acinar epithelium and oncocytic metaplasia in the months following irradiation. The ductular epithelium undergoes squamous changes and within the ductular lumina, secretions become inspissated. The underlying pathogenetic mechanisms for these late irradiation induced changes may be the combination of a direct irradiation effect on acinar epithelium in association with post-obstructive inflammation and ischaemia, secondary to irradiation-induced endarteritis; however, these morphological changes observed may only be the result of an unusual repair phenomenon that salivary tissue is known to go through after any form of noxious stimulation. These histological alterations may lead to a possible misdiagnosis of malignancy in surgical specimens.
唾液腺组织在放疗后的数月内表现出炎症改变、萎缩、替代性纤维化、腺泡上皮显著的多形性和异型性以及嗜酸性化生。小导管上皮发生鳞状化生，在小导管腔内，分泌物变得浓稠。这些放疗后晚期诱导变化的潜在发病机制可能是对腺泡上皮的直接辐射效应与阻塞后炎症和缺血相结合，继发于辐射诱导的动脉内膜炎；然而，观察到的这些形态学变化可能只是唾液腺组织在任何形式的有害刺激后所经历的一种特殊修复现象的结果。这些组织学改变可能导致手术标本中出现恶性肿瘤的误诊。
