Vance M A, Ross S M, Millington W R, Blumberg J B
Clin Toxicol. 1977;11(4):413-21. doi: 10.3109/15563657708988204.
Subtoxic doses of physostigmine have been found to potentiate the convulsive toxicity and lethality of amitriptyline and imipramine in CD1 and B6A mice. Neostigmine failed to potentiate the toxicity and lethality of imipramine. Physostigmine tended to protect mice against atropine-induced lethality. These data suggest the site of toxicity of this drug-drug interaction between the tricyclic antidepressants and physostigmine may be occurring in the CNS through a mechanism distinct from the anticholinergic actions of the antidepressants.
已发现亚中毒剂量的毒扁豆碱可增强阿米替林和丙咪嗪对CD1和B6A小鼠的惊厥毒性和致死性。新斯的明未能增强丙咪嗪的毒性和致死性。毒扁豆碱倾向于保护小鼠免受阿托品诱导的致死性。这些数据表明，三环类抗抑郁药与毒扁豆碱之间这种药物相互作用的毒性部位可能通过一种不同于抗抑郁药抗胆碱能作用的机制发生在中枢神经系统。
