Nagai H, Osuga K, Koda A
Jpn J Pharmacol. 1975 Dec;25(6):763-72. doi: 10.1254/jjp.25.763.
Baicalein, a flavonoid, is anti-allergic but only slightly soluble in water. The soluble derivatives of baicalein, disodium baicalein-6-phosphate (BPS) and sodium baicalein-6-sulfate (BSS), were synthesized and examined regarding their effects on hypersensitivity reactions. These derivatives inhibited type I and II reactions as classified by Coombs and Gell. The Arthus reaction belonging to type III reaction, however, was hardly affected with either BPS or BSS. The experimental asthma caused by passive systemic anaphylaxis in guinea pigs was prevented with application of BPS. Thus even by the oral route, BPS appears to be clinically applicable to extensive allergy related diseases.
黄芩素是一种黄酮类化合物，具有抗过敏作用，但在水中的溶解度很低。合成了黄芩素的可溶性衍生物黄芩素-6-磷酸二钠（BPS）和黄芩素-6-硫酸酯钠（BSS），并研究了它们对过敏反应的影响。这些衍生物抑制了库姆斯和盖尔分类的I型和II型反应。然而，属于III型反应的阿瑟斯反应几乎不受BPS或BSS的影响。应用BPS可预防豚鼠被动全身过敏反应引起的实验性哮喘。因此，即使通过口服途径，BPS似乎在临床上也可用于广泛的过敏相关疾病。
