Yanase M
Endocrinol Jpn. 1977 Oct;24(5):507-12. doi: 10.1507/endocrj1954.24.507.
In order to examine a possible role of adrenaline (AD) or noradrenaline (NA) in the control of lordosis behavior, lordosis quotient (LQ) was observed daily for 8 consecutive days in the ovariectomized rat given daily 1 or 2 microgram/0.1 ml oil of estradiol benzoate (EB) alone or together with 100 microgram/0.1 ml saline of AD or NA. AD but not NA treated together with EB caused a greater change in the daily LQ than the same dose of EB alone and the change in the daily LQ by daily treatment with both 1 microgram EB and 100 microgram AD was equivalent to that by daily treatment with 2 microgram EB alone. A half mg progesterone (P) could induce the lordosis behavior in the ovariectomized rat treated 48 hr prior with both 1 microgram EB and 50 or 100 microgram AD, but not in the one treated with 1 microgram EB alone. While 50, 100 or 200 microgram NA or 10 microgram AD had no effect, 50 or 100 microgram AD pretreated together with 2 microgram EB produced a markedly higher LQ after P than 2 microgram EB alone in the ovariectomized rat. This effect of AD on the induction of lordosis behavior was produced only when AD was pretreated simultaneously with EB and AD priming 24 or 43 hr after EB failed to elicit the effect. Therefore, it is suggested that a change of the brain target site in the estrogen sensitivity produced by AD plays a part in the control of lordosis behavior.
为了研究肾上腺素（AD）或去甲肾上腺素（NA）在控制脊柱前凸行为中的可能作用，对去卵巢大鼠连续8天每日观察脊柱前凸商（LQ），这些大鼠每日单独给予1或2微克/0.1毫升苯甲雌二醇（EB）油剂，或同时给予100微克/0.1毫升AD或NA的生理盐水。与EB一起处理时，AD而非NA导致每日LQ的变化比单独使用相同剂量的EB更大，并且每日同时用1微克EB和100微克AD处理导致的每日LQ变化等同于单独每日用2微克EB处理的变化。半毫克孕酮（P）可在48小时前用1微克EB和50或100微克AD处理的去卵巢大鼠中诱导脊柱前凸行为，但在仅用1微克EB处理的大鼠中则不能。虽然50、100或200微克NA或10微克AD没有作用，但在去卵巢大鼠中，与2微克EB一起预处理50或100微克AD后，给予P产生的LQ明显高于单独使用2微克EB。AD对脊柱前凸行为诱导的这种作用仅在AD与EB同时预处理时产生，并且在EB后24或43小时给予AD启动未能产生该作用。因此，提示AD引起的雌激素敏感性脑靶位点变化在脊柱前凸行为的控制中起作用。
