Endocarditis in mice infected with Coxsackie virus B4.

Endocarditis has not been generally considered to be a complication of viral infection. We show that mural and valvular endocarditis can be produced in mice infected with Coxsackie virus B(4). Because this virus commonly infects man and is highly cardiotropic, it is important to know whether it produces valvular lesions in man similar to those we describe in mice.