慢性锰中毒：关于葡萄糖耐量和血清蛋白的初步观察
Chronic manganism: preliminary observations on glucose tolerance and serum proteins.
作者信息
Hassanein M, Ghaleb H A, Haroun E A, Hegazy M R, Khayyal M A
出版信息
Br J Ind Med. 1966 Jan;23(1):67-70. doi: 10.1136/oem.23.1.67.
Abstract
An intravenous glucose tolerance test was carried out in 11 patients with chronic manganese poisoning. Prolonged reactionary hypoglycaemia was observed. The underlying mechanism is discussed. It may be due to a disturbance of the hypothalamo-pituitary-adrenal axis. In seven of these patients total serum proteins were estimated and were separated electrophoretically. The albumin: globulin ratios were lower in patients than in controls. There were significant reductions in serum albumin concentrations and increases in concentrations of α and β globulins.
摘要
对11例慢性锰中毒患者进行了静脉葡萄糖耐量试验。观察到反应性低血糖持续时间延长。对其潜在机制进行了讨论。这可能是由于下丘脑 - 垂体 - 肾上腺轴功能紊乱所致。对其中7例患者测定了血清总蛋白并进行了电泳分离。患者的白蛋白：球蛋白比值低于对照组。血清白蛋白浓度显著降低，α和β球蛋白浓度升高。
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