Grana E, Zonta F, Dondi P, Piccinini F, Favalli L
Farmaco Sci. 1977 Dec;32(12):897-904.
It has been shown that reserpine competitively antagonises the response of the isolated rat vas deferens to Ca2+. It has also been shown that reserpine does not modify uptake of Ca2+ from the external medium. On the basis of the results obtained and bearing in mind the uncoupling effect of reserpine on oxidative phosphorylation, it is suggested that reserpine owes its "direct" action to reduced availability of Ca2+ for contraction due to metabolic block.
已表明利血平竞争性拮抗离体大鼠输精管对Ca2+的反应。还表明利血平不改变从外部介质摄取Ca2+的情况。根据所获得的结果并考虑到利血平对氧化磷酸化的解偶联作用，有人提出利血平的“直接”作用是由于代谢阻滞导致收缩所需Ca2+的可用性降低。
