Brown P E, Calvin M, Newmark J F
Science. 1966 Jan 7;151(3706):68-70. doi: 10.1126/science.151.3706.68.
When thymine in dilute, deaerated, aqueous solution was irradiated with gamma-rays in the presence of ethanol, a high yield of products containing both the thymine and ethanol moieties was obtained. These were shown to be isomers formed by the attack of CH(3)CHOH radicals at the carbon No. 6 position of thymine. A similar reaction was observed with N, N'-dimethylthymine, but O,O'-dimethylthymine did not react. The reaction may be relevant to the resistance of certain cells to ionizing radiation.
当在乙醇存在下，用γ射线辐照稀的、脱气的胸腺嘧啶水溶液时，可高产率地得到同时含有胸腺嘧啶和乙醇部分的产物。结果表明，这些产物是由CH(3)CHOH自由基进攻胸腺嘧啶的6号碳原子形成的异构体。用N，N'-二甲基胸腺嘧啶也观察到类似反应，但O，O'-二甲基胸腺嘧啶不发生反应。该反应可能与某些细胞对电离辐射的抗性有关。
