肾上腺切除大鼠白色脂肪组织中对胰岛素的敏感性降低。
Decreased sensitivity to insulin in white adipose tissue from adrenalectomised rats.
作者信息
Smith S J, Saggerson E D
出版信息
Horm Metab Res. 1977 Nov;9(6):474-80. doi: 10.1055/s-0028-1093503.
PMID:590921
Abstract
The ability of insulin to increase both [14C]-glucose incorporation into fatty acids and pyruvate dehydrogenase activity in incubated rat epididymal adipose tissues was considerably lessened after adrenalectomy. Insulin antagonism of adrenaline-stimulated lipolysis in isolated fat cells was abolished after adrenalectomy. Percentage stimulation of lipolysis above basal by adrenaline was not appreciably altered by adrenalectomy.
摘要
肾上腺切除术后，胰岛素增加孵育的大鼠附睾脂肪组织中[14C] - 葡萄糖掺入脂肪酸以及丙酮酸脱氢酶活性的能力显著降低。肾上腺切除术后，胰岛素对分离脂肪细胞中肾上腺素刺激的脂解作用的拮抗作用消失。肾上腺切除术对肾上腺素刺激脂解作用使其高于基础水平的百分比没有明显改变。
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