Collipp P J, Irani N G, Plachte F
Calif Med. 1966 Apr;104(4):278-83.
Among 74 patients with congenital adrenal hyperplasia observed at Childrens Hospital, Los Angeles, in a 25-year period, 36 had the simple virilizing type and 38 the salt-losing type. During the same time, seven children with virilizing adrenal tumors were observed at the hospital. While virilization and dehydration were the most common presenting symptoms, some of the children first came to medical attention because of other symptoms, and 11 of them died before adrenal hyperplasia had been diagnosed. Twenty-eight additional congenital cardiovascular, genitourinary, and gastrointestinal anomalies were found in 16 of these 74 children. With proper management, the patients tolerated such stresses as surgical operation and infections without difficulty.
在洛杉矶儿童医院25年间观察的74例先天性肾上腺皮质增生症患者中，36例为单纯男性化型，38例为失盐型。同期，该院观察到7例男性化肾上腺肿瘤患儿。虽然男性化和脱水是最常见的首发症状，但有些患儿最初因其他症状就医，其中11例在先天性肾上腺皮质增生症被诊断之前死亡。在这74例患儿中的16例还发现了另外28种先天性心血管、泌尿生殖和胃肠道异常。经过适当治疗，患者能够顺利耐受手术和感染等应激情况。
