Trotter S L, Franklin R M, Baas E J, Barile M F
Infect Immun. 1977 Dec;18(3):816-22. doi: 10.1128/iai.18.3.816-822.1977.
The induction of caprine keratoconjunctivitis by the subconjunctival inoculation of a cloned culture of Mycoplasma conjunctivae is described. The clinical course of the experimental disease was similar to that noted in naturally occurring outbreaks of "pink-eye" among goats, and biopsies of inflamed conjunctivae showed similar histological response. M. conjunctivae was consistently recovered from the inflamed conjunctival tissues of inoculated animals that developed ocular disease, thus fulfilling Koch's postulates and establishing this organism as an etiological agent of caprine keratoconjunctivitis. Immunological studies suggested that cellular immune mechanisms may play a role in protecting animals from disease produced by this mycoplasma.
本文描述了通过结膜下接种结膜支原体克隆培养物诱导山羊角膜结膜炎的过程。实验性疾病的临床病程与山羊自然发生的“红眼病”暴发中观察到的病程相似，炎症结膜的活检显示出相似的组织学反应。从发生眼部疾病的接种动物的炎症结膜组织中持续分离出结膜支原体，从而满足了科赫法则，并确定该微生物为山羊角膜结膜炎的病原体。免疫学研究表明，细胞免疫机制可能在保护动物免受这种支原体引起的疾病方面发挥作用。
