维生素A代谢的研究。维生素A缺乏阶段对大鼠肝脏中硫酸盐活化的影响。
Studies on metabolism of vitamin A. The effect of the stage of vitamin A deficiency on sulphate activation in rat liver.
作者信息
Rao K S, Ganguly J
出版信息
Biochem J. 1966 Mar;98(3):693-5. doi: 10.1042/bj0980693.
Abstract
- The synthesis of ;active sulphate' in rat liver was studied at various stages of vitamin A deficiency, with the corresponding pair-fed controls. 2. The activity was significantly decreased even at the onset of the deficiency, and at the acute stage there was further loss. 3. Only at the earlier stages of the deficiency was the addition of retinol, in vitro, fully effective in restoring the lost activity; retinoic acid was partially active. No such restoration was possible at the acute deficiency stage.
摘要
- 对维生素A缺乏不同阶段的大鼠肝脏中“活性硫酸盐”的合成进行了研究，并设置了相应的配对喂食对照组。2. 即使在缺乏症刚开始时，其活性就显著降低，在急性期进一步丧失。3. 仅在缺乏症的早期阶段，体外添加视黄醇能完全有效恢复丧失的活性；视黄酸有部分活性。在急性缺乏阶段则无法进行这种恢复。
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引用本文的文献
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Role of vitamin A in sulphate metabolism. Studies on the enzymic activation of sulphate by various tissue extracts of normal and vitamin A-deficient rats.维生素A在硫酸盐代谢中的作用。对正常和维生素A缺乏大鼠的各种组织提取物中硫酸盐的酶促活化的研究。
Biochem J. 1967 Jul;104(1):318-20. doi: 10.1042/bj1040318.
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Biochem J. 1966 Apr;99(1):138-45. doi: 10.1042/bj0990138.
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The activation of sulphate by extracts of cornea and colonic mucosa from normal and vitamin A-deficient animals.正常及维生素A缺乏动物的角膜和结肠黏膜提取物对硫酸盐的激活作用。
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Nature. 1961 Feb 11;189:482. doi: 10.1038/189482a0.
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