大鼠脑中细胞膜硫脂的代谢
Metabolism of cellular membrane sulpholipids in the rat brain.
作者信息
Davison A N, Gregson N A
出版信息
Biochem J. 1966 Mar;98(3):915-22. doi: 10.1042/bj0980915.
Abstract
- Metabolism of [(35)S]sulpholipid was studied in rats of different ages after the injection of [(35)S]sulphate. 2. The turnover of sulphatide in brain myelin and subcellular fractions was followed for long periods. 3. A small fraction of adult myelin underwent rapid metabolism, the rest being relatively metabolically stable. 4. Fast turnover of brain microsomal sulphatide during development was related to the process of myelination. 5. Turnover of mitochondrial sulphatide was at a lower rate than that calculated for liver mitochondria. 6. The relevance of the results to the metabolism of the whole membrane is discussed.
摘要
- 在注射[³⁵S]硫酸盐后，研究了不同年龄大鼠中[³⁵S]硫脂的代谢情况。2. 对脑髓鞘和亚细胞组分中硫苷脂的周转进行了长期跟踪。3. 一小部分成年髓鞘经历快速代谢，其余部分代谢相对稳定。4. 发育过程中脑微粒体硫苷脂的快速周转与髓鞘形成过程有关。5. 线粒体硫苷脂的周转速率低于肝脏线粒体的计算速率。6. 讨论了这些结果与整个膜代谢的相关性。
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