寡霉素和某些硝基酚对蛙胃黏膜酸分泌及氧摄取的影响。
The effect of oligomycin and some nitrophenols on acid secretion and oxygen uptake by gastric mucosa of the frog.
作者信息
Bannister W H
出版信息
J Physiol. 1966 Sep;186(1):89-96. doi: 10.1113/jphysiol.1966.sp008021.
Abstract
- The ability of the three nitrophenols, m-nitrophenol, p-nitrophenol and 2,4-dinitrophenol, to inhibit acid secretion and stimulate oxygen uptake by gastric mucosa paralleled their extent of dissociation at physiological pH.2. Oligomycin inhibited oxygen uptake by gastric mucosa, and showed a tendency to inhibit acid secretion.3. 2,4-dinitrophenol lowered the value of the ratio between acid secretion and the associated oxygen uptake. Oligomycin did not affect the value of this ratio.4. It would appear that a non-phosphorylated high-energy intermediate of oxidative phosphorylation might be involved in acid secretion by gastric mucosa.
摘要
间硝基苯酚、对硝基苯酚和2,4-二硝基苯酚这三种硝基苯酚抑制胃酸分泌和刺激胃黏膜摄氧量的能力与它们在生理pH值下的解离程度相当。
寡霉素抑制胃黏膜的摄氧量，并显示出抑制胃酸分泌的趋势。
2,4-二硝基苯酚降低了胃酸分泌与相关氧摄取之间的比值。寡霉素不影响该比值。
似乎氧化磷酸化的一种非磷酸化高能中间体可能参与胃黏膜的胃酸分泌。
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