Miller A K, Celozzi E, Pelak B A
J Antibiot (Tokyo). 1977 Nov;30(11):983-6. doi: 10.7164/antibiotics.30.983.
Novobiocin demonstrates an effect similar to that of probenecid (the "probenecid effect") in enhancing the therapeutic efficacy of antibiotics excreted mainly by the renal tubules. The ability of cefoxitin, cephalexin, cephalothin and penicillin G to protect mice against infection with Salmonella schottmuelleri was enhanced 2- to 3-fold when the animals were given oral doses of either probenecid or of novobiocin. The efficacy of cephaloridine, excreted mainly by glomerular filtration, was not enhanced by either probenecid or by novobiocin.
新生霉素在增强主要经肾小管排泄的抗生素的治疗效果方面，表现出与丙磺舒类似的作用（“丙磺舒效应”）。当给小鼠口服丙磺舒或新生霉素时，头孢西丁、头孢氨苄、头孢噻吩和青霉素G保护小鼠免受肖特穆勒沙门氏菌感染的能力提高了2至3倍。主要经肾小球滤过排泄的头孢噻啶的疗效，未因丙磺舒或新生霉素而增强。
