Thind K S
Immunology. 1966 Jul;11(1):59-65.
The intravenous transfer of mesenteric lymph node cells from intragastrically immunized donors led to the appearance of agglutinins in the sera of recipients. Other lymph node cells from these donors did not impart such a response in the recipients. The serum agglutinin titres in recipients were dependent on the immune state of the donor where the better immunization of the donor gave a high and prolonged response in the recipients. The antibody synthesizing property could be conveyed to the recipients by the intravenous transfer of any of the lymph node cells and spleen tissue using intravenously immunized donors. However, in intragastrically immunized donors, it was only the mesenteric lymph node cells that could effectively transfer this factor. Thus, the sensitization of the regional lymph nodes is important in cell transfer mechanism. The antibody that appeared in recipients after the cell transfer was not due to the transfer of preformed antibody but was due to the active participation of the recipient in the antibody synthesis. The lymph node cells tested were negative for agglutinins.
将经胃内免疫的供体的肠系膜淋巴结细胞进行静脉内转移，导致受体血清中出现凝集素。来自这些供体的其他淋巴结细胞在受体中未引发这种反应。受体血清中的凝集素滴度取决于供体的免疫状态，供体免疫效果越好，受体中的反应就越高且持续时间越长。使用经静脉免疫的供体，通过静脉内转移任何淋巴结细胞和脾脏组织，抗体合成特性都可以传递给受体。然而，在经胃内免疫的供体中，只有肠系膜淋巴结细胞能够有效地转移这种因子。因此，区域淋巴结的致敏在细胞转移机制中很重要。细胞转移后受体中出现的抗体不是由于预先形成的抗体的转移，而是由于受体积极参与抗体合成。所检测的淋巴结细胞凝集素呈阴性。
