Taborsky R G, Delvigs P, Page I H
Science. 1966 Aug 26;153(3739):1018-20. doi: 10.1126/science.153.3739.1018.
6-Hydroxy-5-methoxy-N,N dimethyltryptamine and 5-methoxy-N, N-dimnethyltryptamine were synthesized and their psychotropic effects compared on trained rats in a Skinner box. The nonhydroxylated form was the more po tent. The metabolism of 5-methoxytryp tophol acetate ester was also studied to determine whether hydroxylation might occur in other than the six position with exogenous indoles. One metabolite was formed, with properties of a hydroxy-5-methoxyindole-3-acetic acid, which proved on chromatography not to be the 6-hydroxy structural isomer. Phar macologic and metabolic studies suggest that psychotropic activity of trypt amines may result from metabolites other than the 6-hydroxylated forms.
合成了6-羟基-5-甲氧基-N,N-二甲基色胺和5-甲氧基-N,N-二甲基色胺，并在斯金纳箱中对训练过的大鼠比较了它们的精神作用。未羟基化的形式活性更强。还研究了5-甲氧基色醇乙酸酯的代谢，以确定在外源性吲哚的情况下，羟基化是否可能发生在除6位以外的其他位置。形成了一种代谢产物，具有羟基-5-甲氧基吲哚-3-乙酸的性质，色谱分析证明它不是6-羟基结构异构体。药理和代谢研究表明，色胺的精神活性可能来自于除6-羟基化形式以外的代谢产物。
