Boyer S H, Hathaway P, Pascasio F, Orton C, Bordley J, Naughton M A
Science. 1966 Sep 23;153(3743):1539-43. doi: 10.1126/science.153.3743.1539.
Among the three adult sheep hemoglobins (A, B, and C), two (A and B) are reportedly products of alleles. The beta-chains of A and B differ by at least seven scattered amino acid residues whereas the beta-sequence of C differs from A by at least 16 residues and from B by at least 21 residues. These changes suggest that the origin of C-beta antedated the divergence of A and B. Five shared differences between A-beta and C-beta with respect to B-beta can be interpreted as the result of selective advantage in favor of B. A complex of additional mechanisms has possibly been involved in maintaining the A-B- C porymorphism.
在三种成年绵羊血红蛋白（A、B和C）中，据报道其中两种（A和B）是等位基因的产物。A和B的β链至少有七个分散的氨基酸残基不同，而C的β序列与A至少有16个残基不同，与B至少有21个残基不同。这些变化表明C-β的起源早于A和B的分化。A-β和C-β相对于B-β的五个共同差异可以解释为有利于B的选择优势的结果。可能有一系列额外的机制参与维持A-B-C多态性。
