Al-Hindawi A Y, Black E G, Brewer D B, Griffiths S G, Hoffenberg R
J Endocrinol. 1977 Nov;75(2):245-50. doi: 10.1677/joe.0.0750245.
Rats treated with 131I and propylthiouracil were shown to develop thyroid tumours 7--9 months after treatment. In this group, the levels of total thyroxine and tri-iodothyronine, and free thyroxine and tri-iodothyronine in the serum were low, and that of TSH was raised. In a group of rats treated with 131I and then propylthiouracil and thyroxine, thyroid tumours were found despite normal concentrations of total and free thyroxine and tri-iodothyronine in the serum. The level of TSH in the serum was significantly raised in this group. Thyroid tumours were not found in the various control groups of rats.
经131I和丙硫氧嘧啶治疗的大鼠在治疗后7至9个月出现甲状腺肿瘤。在该组中，血清总甲状腺素、三碘甲状腺原氨酸、游离甲状腺素和游离三碘甲状腺原氨酸水平较低，促甲状腺激素（TSH）水平升高。在一组先经131I治疗，然后给予丙硫氧嘧啶和甲状腺素的大鼠中，尽管血清总甲状腺素、游离甲状腺素、总三碘甲状腺原氨酸和游离三碘甲状腺原氨酸浓度正常，但仍发现了甲状腺肿瘤。该组大鼠血清TSH水平显著升高。在各大鼠对照组中未发现甲状腺肿瘤。
