安氟醚、异氟醚、氟烷、甲氧氟烷和乙醚麻醉对犬哇巴因耐受性的影响。

The effect of enflurane, isoflurane, fluroxene, methoxyflurane and diethyl ether anesthesia on ouabain tolerance in the dog.

作者信息

Ivankovich A D, Miletich D J, Grossman R K, Albrecht R F, El-Etr A A, Cairoli V J

出版信息

Anesth Analg. 1976 May-Jun;55(3):360-5. doi: 10.1213/00000539-197605000-00017.

DOI:10.1213/00000539-197605000-00017

Abstract

Digitalis tolerance in dogs anesthetized with enflurane, isoflurane, fluroxene, methoxyflurane, and diethyl ether was compared with that in dogs anesthetized with pentobarbital. Ouabain dosage needed to cause ventricular tachycardia was significantly higher than that of pentobarbital with all agents except fluroxene, as was the LD50. The relative potency of these anesthetics in converting ouabain-induced ventricular tachycardia to sinus rhythm, in order of descending effectiveness, was: diethyl ether, methoxyflurane, enflurane, fluroxene, isoflurane, pentobarbital.

摘要

将用恩氟烷、异氟烷、氟烷、甲氧氟烷和乙醚麻醉的犬的洋地黄耐受性与用戊巴比妥麻醉的犬进行了比较。除氟烷外，所有麻醉剂导致室性心动过速所需的哇巴因剂量均显著高于戊巴比妥，半数致死量也是如此。这些麻醉剂将哇巴因诱导的室性心动过速转为窦性心律的相对效力，按有效性递减顺序为：乙醚、甲氧氟烷、恩氟烷、氟烷、异氟烷、戊巴比妥。