利用分子连接性对致幻性苯丙胺类药物进行构效关系研究。
Structure-activity studies on hallucinogenic amphetamines using molecular connectivity.
作者信息
Kier L B, Hall L H
出版信息
J Med Chem. 1977 Dec;20(12):1631-6. doi: 10.1021/jm00222a019.
PMID:592329
Abstract
A series of ring-substituted hallucinogenic amphetamines has been analyzed using molecular connectivity. A correlating equation has been found between potency and connectivity terms. The equation permits an interpretation of SAR. The equation is capable of predicting potency for amphetamines not in the list and mescalines and tryptamines.
摘要
使用分子连接性分析了一系列环取代的致幻苯丙胺。在效力与连接性项之间发现了一个相关方程。该方程允许对构效关系进行解释。该方程能够预测未在列表中的苯丙胺、三甲氧苯乙胺和色胺的效力。
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