Uchida Y, Yoshimoto N, Murao S, Inoue K
Jpn Circ J. 1977 Nov;41(11):1221-30. doi: 10.1253/jcj.41.1221.
Mechanisms for cyclical reduction in peripheral blood pressure and flow of partially constricted coronary artery of anesthetized dogs has been examined. In 64 of 97 preparations, cyclical reduction in coronary blood pressure and flow developed 3 to 32 min after the beginning of constriction. Period duration of the cyclical reduction ranged from 1 to 32 min. The cyclical reduction was frequently associated with elevation of the ST segment of surface electrocardiogram, systolic bulge of the left ventricle and excitation of afferent cardiac sympathetic nerve fibers. In the preparations in which cyclical reduction was not produced by constriction, a brief stretching of the constricted portion provoked the cyclical reduction. Segmental or diffuse narrowing of the constricted coronary artery which occurred during the reduction in pressure and flow was demonstrated by selective arteriography. Also, segmental spasm in the constricted coronary artery was demonstrated by photography. No obvious difference in the constricted of the artery was observed histologically between the preparations in which cyclical reduction developed and those in which cyclical reduction was not produced. The results indicate participation of vasospasm in the cyclical reduction of blood pressure and flow in partially constricted coronary artery.
已对麻醉犬部分狭窄冠状动脉外周血压和血流的周期性降低机制进行了研究。在97个实验标本中，有64个在开始狭窄后3至32分钟出现冠状动脉血压和血流的周期性降低。周期性降低的周期持续时间为1至32分钟。这种周期性降低常伴有体表心电图ST段抬高、左心室收缩期膨隆以及心脏传入交感神经纤维兴奋。在狭窄未产生周期性降低的标本中，对狭窄部位进行短暂牵拉可引发周期性降低。选择性动脉造影显示，在压力和血流降低期间，狭窄冠状动脉出现节段性或弥漫性狭窄。此外，通过摄影证实了狭窄冠状动脉存在节段性痉挛。在出现周期性降低和未出现周期性降低的标本之间，从组织学上观察到动脉狭窄情况无明显差异。结果表明，血管痉挛参与了部分狭窄冠状动脉血压和血流的周期性降低。
