Saito T, Yamada Y
Jpn J Antibiot. 1977 Oct;30(10):835-9.
The excretion of T-1220 in bile was evaluated in 4 patients with biliary tract diseases. The bile was collected for 6 hours after intravenous injection of T-1220. The maximal concentration in bile was 1,600 mcg/ml at 0.5 approximately 1 hour after administration of 1 g of T-1220 to 1 case. In 3 cases treated with 2 g, the maximal concentration was 155 approximately 1,115 mcg/ml at 2 approximately 3 hours after administration. Total excretion rates in bile after 0 approximately 6 hours were 0.5 approximately 7.2%. T-1220 was applied clinically to 3 patients with biliary tract infections. Clinical results obtained were good in all cases. No side effect was observed in all cases.
对4例胆道疾病患者评估了T - 1220的胆汁排泄情况。静脉注射T - 1220后收集6小时胆汁。给1例患者静脉注射1g T - 1220后，胆汁中的最大浓度在给药后0.5至1小时达到1600 mcg/ml。在3例接受2g T - 1220治疗的患者中，给药后2至3小时的最大浓度为155至1115 mcg/ml。给药后0至6小时胆汁中的总排泄率为0.5至7.2%。T - 1220临床应用于3例胆道感染患者。所有病例的临床结果均良好。所有病例均未观察到副作用。
