Fox J G, Niemi S M, Murphy J C, Quimby F W
Lab Anim Sci. 1977 Oct;27(5 Pt 1):671-8.
Ulcerative dermatitis observed in several shipments of rats was found to be limited to one strain (Sprague Dawley) provided by one supplier from two specific breeding areas. The incidence of lesions was higher in males than in females. Rats receiving an agar base diet also appeared to have a higher incidence of the lesions. The lesion consisted of a moist ulcer usually involving the lateral aspect of the shoulder and often the sides of the neck. Staphylococcus aureus was isolated from lesions of affected rats and from the skin of unaffected rats. Inoculation of S aureus into susceptible animals resulted in lesions in 25-40% of the rats, but usually at sites other than the site of inoculation. Serum neutralization tests for sialodacryoadenitis virus indicated that about half the rats with lesions and half the rats without lesions were positive. Toenail clipping of the hind feet of affected rats reduced the severity of the lesions. Efforts to isolate fungi and ectoparasites were unsuccessful. The selective procurement of rats from specified breeding areas, eliminated the population susceptible to or harboring the etiologic agent or agents responsible for the development of the ulcerative dermatitis described.
在几批大鼠中观察到的溃疡性皮炎仅限于来自两个特定繁殖区域的一家供应商提供的一个品系（斯普拉格-道利大鼠）。雄性大鼠的损伤发生率高于雌性。接受琼脂基饮食的大鼠似乎损伤发生率也更高。损伤表现为湿性溃疡，通常累及肩部外侧，常伴有颈部两侧。从患病大鼠的损伤部位以及未患病大鼠的皮肤中分离出了金黄色葡萄球菌。将金黄色葡萄球菌接种到易感动物体内，25%-40%的大鼠出现了损伤，但通常发生在接种部位以外的部位。涎泪腺炎病毒的血清中和试验表明，约一半有损伤的大鼠和一半无损伤的大鼠呈阳性。剪掉患病大鼠后足的趾甲可减轻损伤的严重程度。分离真菌和体外寄生虫的努力未成功。从特定繁殖区域选择性采购大鼠，消除了易患或携带导致所述溃疡性皮炎病原体的种群。
