Saunders R N, Burns T S, Stelzer M R, Waskawic E R
Lab Anim Sci. 1977 Oct;27(5 Pt 2):757-61.
Spontaneous circulating platelet aggregates were observed in male retired breeder rats but in nonbred males of the same age and strain. Fasting serum lipid, platelet serotonin, and platelet rich plasma cyclic guanosine monophosphate levels were similar in retired breeders and nonbred rats. The in vitro response of platelets from retired breeder and nonbred rats to adenosine diphosphate and collagen were also similar. Administration of prostaglandin E1 and antiplatelet drugs (acetylsalicylic acid, sulfinpyrazone, and dipyridamole) reduced the number of circulating platelet aggregates in the breeder rats. It was concluded that the retired breeder rat may be a useful model for identification of new anti-platelet drugs.
在雄性退休繁殖大鼠中观察到自发性循环血小板聚集体，但在相同年龄和品系的未繁殖雄性大鼠中未观察到。退休繁殖大鼠和未繁殖大鼠的空腹血脂、血小板血清素以及富含血小板血浆中的环磷酸鸟苷水平相似。退休繁殖大鼠和未繁殖大鼠的血小板对二磷酸腺苷和胶原的体外反应也相似。给予前列腺素E1和抗血小板药物（乙酰水杨酸、磺吡酮和双嘧达莫）可减少繁殖大鼠循环血小板聚集体的数量。得出的结论是，退休繁殖大鼠可能是鉴定新型抗血小板药物的有用模型。
