Nishioka K, Romsdahl M M, McMurtrey M J
J Surg Oncol. 1977;9(6):555-62. doi: 10.1002/jso.2930090605.
Polyamines, by virture of their regulatory role in the cellular synthesis of DNA, RNA, and protein, are potential indicators of malignant growth. In view of this, serum polyamine levels of patients with colorectal carcinoma or benign bowel disease were examined. Of 53 patients with colorectal carcinoma, 35 (66%) showed elevations of 1 or more polyamines. Nine patients with benign bowel disease (villous adenoma, Gardner's syndrome, familial polyposis, and diverticulitis) showed normal serum polyamine levels except 1 patient with a villous adenoma. Patients with colorectal carcinoma were designated stage A, B, C, or D depending on the progression of their disease. All patients classified as D showed elevation of 1 or more polyamines. Serum polyamines became elevated following surgery in patients with colorectal carcinoma as well as those with benign bowel diseases, suggesting a relationship to the surgical procedure. Preliminary longitudinal studies of patients with colorectal carcinoma (B stage) undergoing curable surgical procedures show normal polyamine levels and no evidence of disease at 15 months.
多胺由于其在DNA、RNA和蛋白质细胞合成中的调节作用，是恶性生长的潜在指标。鉴于此，对结直肠癌或良性肠道疾病患者的血清多胺水平进行了检测。53例结直肠癌患者中，35例（66%）显示1种或多种多胺升高。9例良性肠道疾病（绒毛状腺瘤、加德纳综合征、家族性息肉病和憩室炎）患者除1例绒毛状腺瘤患者外，血清多胺水平均正常。根据疾病进展情况，将结直肠癌患者分为A、B、C或D期。所有分类为D期的患者均显示1种或多种多胺升高。结直肠癌患者以及良性肠道疾病患者术后血清多胺均升高，提示与手术操作有关。对接受可治愈性手术的结直肠癌（B期）患者进行的初步纵向研究显示，15个月时多胺水平正常且无疾病证据。
