Schreiber H W, Schumpelick V
Langenbecks Arch Chir. 1977 Nov;345:189-92.
"Anyone who claims to have discovered the ideal procedure in the treatment of gastric ulcer, should be considered immodest." These words by Schnitzler (1914) are in principle still valid. The pathogenesis and operative procedure are not identical. There is still no conclusive proof of the pathogenesis. The disclosure of other pathogenetic factors and facts is gradual. Locally active chemical noxae (e.g., propionitril) are responsible for the development of duodenal ulcer. Gastric ulcer is caused by the reflux of duodenal juice (e.g., lysolecithin, which is capable of corroding the mucosal barrier of the stomach. The current pathogenetic mechanisms of ulcer of the usual locations are specified.
施尼茨勒（1914年）说过：“任何声称已发现治疗胃溃疡理想方法的人，都应被视为自不量力。”从原则上讲，这句话至今仍然适用。胃溃疡的发病机制和手术方法并不相同。目前仍没有确凿的发病机制证据。其他致病因素和事实是逐渐被揭示的。局部活性化学毒物（如丙腈）是十二指肠溃疡发病的原因。胃溃疡是由十二指肠液反流引起的（如溶血卵磷脂，它能够腐蚀胃黏膜屏障）。文中明确了常见部位溃疡的当前发病机制。
