一项利用长期全身示踪测量法对人体钙代谢进行的初步研究。
A preliminary study of human calcium metabolism using long-term whole body tracer measurements.
作者信息
Harrison J E, McNeill K G, Finlay J M, Sheppard R H, Mortimer D C
出版信息
Can Med Assoc J. 1966 May 21;94(21):1092-7.
Long-term bone calcium metabolism was measured using a whole body counter apparatus and the radioisotopes calcium-47 and strontium-85. Strontium was given with calcium in a single intravenous injection in order to estimate long-term retention of calcium. Calcium-47, with a short radio-active half-life, was measured directly for 20 days, and then indirectly from strontium retention for periods up to 200 days.The standard parameters of calcium transport were measured and, as well, a new parameter, calcium accretion to the fixed bone pool. These studies were carried out on 13 subjects, six of whom were selected "normals" and seven were patients with osteoporosis. Calcium accretion to the fixed bone pool, the new index of bone formation, varied from 100 to 210 mg. of calcium daily in normal subjects and from 70 to 340 mg./day in patients with osteoporosis. These values are one-third of those for the accretion to the total bone pool, the previously reported bone formation rate.
使用全身计数器设备以及放射性同位素钙-47和锶-85来测量长期骨钙代谢。为了评估钙的长期潴留情况，将锶与钙一起进行单次静脉注射。钙-47的放射性半衰期较短，直接测量20天，然后通过锶潴留情况间接测量长达200天的时间。测量了钙转运的标准参数，同时还测量了一个新参数，即钙向固定骨池的积聚。这些研究在13名受试者身上进行，其中6名被选为“正常”受试者，7名是骨质疏松症患者。钙向固定骨池的积聚是骨形成的新指标，正常受试者每天的钙积聚量在100至210毫克之间，骨质疏松症患者为70至340毫克/天。这些值是之前报道的骨形成率，即钙向总骨池积聚量的三分之一。
Zotero 插件