Kawiak W, Nowicki J, Gieracz-Nazar A
Neurol Neurochir Pol. 1977 Sep-Oct;11(5):545-9.
The investigations were carried out in 10 patients with epileptic seizures. The obtained results were compared with those in a control group of 20 healthy subjects. The 24-hour urinary excretion of 5-HIAA efore hydantoinal and on the 1st, 2dn and 3rd days of hydantoinal administration was determined by the method of Udenfried et al. as modified by McFarlane et al. It was found that healthy subjects excreted significantly more 5-HIAA before and after hydantoinal load. Administration of this drug increased significantly the excretion of this metabolite with urine, in healthy subjects but in epileptics it had no significant effect on 5-HIAA level in 24-hour urine.
对10例癫痫发作患者进行了调查。将所得结果与20名健康受试者的对照组结果进行比较。采用Udenfried等人的方法并经McFarlane等人修改，测定了服用苯妥英前以及服用苯妥英第1、2和3天24小时尿中5-羟吲哚乙酸（5-HIAA）的排泄量。结果发现，健康受试者在服用苯妥英前后排泄的5-HIAA明显更多。该药物的服用显著增加了健康受试者尿液中这种代谢物的排泄，但对癫痫患者24小时尿液中的5-HIAA水平没有显著影响。
