多萜生物合成抑制剂对支原体的生长抑制作用及其被胆固醇逆转的现象。
Growth inhibition of Mycoplasma by inhibitors of polyterpene biosynthesis and its reversal by cholesterol.
作者信息
Smith P F, Henrikson C V
出版信息
J Bacteriol. 1966 May;91(5):1854-8. doi: 10.1128/jb.91.5.1854-1858.1966.
Smith, Paul F. (University of South Dakota, Vermillion), and Carl V. Henrikson. Growth inhibition of Mycoplasma by inhibitors of polyterpene biosynthesis and its reversal by cholesterol. J. Bacteriol. 91:1854-1858. 1966.-Compounds which inhibit enzymatic reactions in the biosynthetic pathway to carotenoids inhibited growth of a sterol-nonrequiring species, Mycoplasma laidlawii, strain B, and M. hominis, strain 07. Since M. hominis lacks the enzymes for polyterpene biosynthesis, the inhibitory compounds must act also at other sites. Most inhibitors exerted a lytic effect at bactericidal levels. The inhibition of M. laidlawii is reversed by exogenous cholesterol. M. laidlawii exhibited a greatly increased content of cholesterol and a greatly decreased content of carotenoids when grown in the presence of phenethylbiguanide and cholesterol. These results are considered as further evidence for a common function for sterols and carotenols in Mycoplasma.
史密斯，保罗·F.（南达科他大学，弗米利恩），以及卡尔·V. 亨里克森。多萜生物合成抑制剂对支原体的生长抑制作用及其被胆固醇逆转的现象。《细菌学杂志》91:1854 - 1858。1966年。——抑制类胡萝卜素生物合成途径中酶促反应的化合物抑制了一种不需要固醇的支原体——莱氏无胆甾原体B株和人型支原体07株的生长。由于人型支原体缺乏多萜生物合成所需的酶，所以这些抑制性化合物必定还作用于其他位点。大多数抑制剂在杀菌浓度时具有溶解作用。莱氏无胆甾原体的生长抑制作用可被外源性胆固醇逆转。当莱氏无胆甾原体在苯乙双胍和胆固醇存在的情况下生长时，其胆固醇含量大幅增加，类胡萝卜素含量大幅降低。这些结果被视为固醇和类胡萝卜醇在支原体中具有共同功能的进一步证据。
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