失神经和重新神经支配肌肉对去极化药物敏感性增加的研究。
A study of the increased sensitivity of denervated and re-innervated muscle to depolarizing drugs.
作者信息
Maclagan J, Vrbová G
出版信息
J Physiol. 1966 Jan;182(1):131-43. doi: 10.1113/jphysiol.1966.sp007813.
Abstract
- The response of re-innervated muscles to depolarizing blocking drugs was studied.2. During the early stages of re-innervation the ;new' neuromuscular junctions are more sensitive to decamethonium and suxamethonium. The recovery from the block and the repolarization of the end-plate are markedly slowed.3. This increased sensitivity does not appear to be characteristic of all newly formed neuromuscular junctions. It was found that in new-born kittens the muscles are very insensitive to neuromuscular blocking drugs.4. It is concluded that the increased sensitivity of re-innervated muscles to depolarizing blocking drugs and the slow repolarization are due to a persistence of changes which developed during denervation.
摘要
研究了重新神经支配的肌肉对去极化阻滞药物的反应。
在重新神经支配的早期阶段，“新的”神经肌肉接头对十烃季铵和琥珀酰胆碱更为敏感。阻滞的恢复和终板的复极化明显减慢。
这种增加的敏感性似乎并非所有新形成的神经肌肉接头所特有。已发现新生小猫的肌肉对神经肌肉阻滞药物非常不敏感。
得出的结论是，重新神经支配的肌肉对去极化阻滞药物的敏感性增加以及复极化缓慢是由于去神经支配期间发生的变化持续存在。
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