外周变化在决定横纹肌对去极化药物敏感性方面的重要性。
The importance of peripheral changes in determining the sensitivity of striated muscle to depolarizing drugs.
作者信息
Maclagan J, Vrbová G
出版信息
J Physiol. 1966 Jun;184(3):618-30. doi: 10.1113/jphysiol.1966.sp007935.
Abstract
- The sensitivity of the flexor digitorum longus and soleus muscles to depolarizing drugs was tested after cross-union of their respective motor nerves.2. The alien innervation did not affect the sensitivity of either the flexor digitorum longus (FDL) or soleus muscles, which retained their normal characteristic responses to decamethonium and suxamethonium. The time course of muscle contractions was, however, altered by the cross-union operation.3. A considerable increase in sensitivity to depolarizing drugs was shown after de-afferentation and after tenotomy of the soleus muscles. Both these conditions are associated with muscle atrophy.4. It is suggested that hypersensitivity to depolarizing drugs can be expected in any situation where the muscle is undergoing atrophy.
摘要
在分别将趾长屈肌和比目鱼肌的运动神经交叉吻合后，检测了这两块肌肉对去极化药物的敏感性。
异体神经支配并未影响趾长屈肌（FDL）或比目鱼肌的敏感性，它们对十烃季铵和琥珀酰胆碱仍保留正常的特征性反应。然而，交叉吻合手术改变了肌肉收缩的时间进程。
在比目鱼肌去传入神经和切断跟腱后，其对去极化药物的敏感性显著增加。这两种情况均与肌肉萎缩有关。
有人提出，在任何肌肉发生萎缩的情况下，都可能出现对去极化药物的超敏反应。
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