肝脏疾病的比较免疫学研究。
Comparative immunological studies in liver diseases.
作者信息
Szécsey G, Dóbiás G, Kerekes E
出版信息
J Clin Pathol. 1966 May;19(3):275-8. doi: 10.1136/jcp.19.3.275.
Abstract
By fractionation of human liver tissue, nuclear, mitochondrial, and connective tissue antigens were prepared. According to the results of serological tests, in conditions associated with substantial damage to the hepatic parenchyma, antibodies reacting with the nuclear and mitochondrial antigens are produced that show practically no reaction with the connective tissue antigen. It is advisable to use fractionated, connective tissue-free antigens for the demonstration of antibodies formed against liver tissue. The use of antigens containing connective tissue may lead to non-specific reactions.
摘要
通过对人肝组织进行分级分离，制备了核抗原、线粒体抗原和结缔组织抗原。根据血清学检测结果，在肝实质受到严重损伤的情况下，会产生与核抗原和线粒体抗原发生反应的抗体，而这些抗体与结缔组织抗原几乎不发生反应。为了检测针对肝组织产生的抗体，宜使用无结缔组织的分级分离抗原。使用含有结缔组织的抗原可能会导致非特异性反应。
相似文献
1
Comparative immunological studies in liver diseases.肝脏疾病的比较免疫学研究。
J Clin Pathol. 1966 May;19(3):275-8. doi: 10.1136/jcp.19.3.275.
2
[Diagnosis of the immunopathologic reactions in liver diseases].[肝脏疾病免疫病理反应的诊断]
Med Klin. 1976 Sep 3;71(36):1401-12.
3
Antithyroglobulin monoclonal and autoantibodies cross-react with an orbital connective tissue membrane antigen: a possible mechanism for the association of ophthalmopathy with autoimmune thyroid disorders.抗甲状腺球蛋白单克隆抗体和自身抗体与眼眶结缔组织膜抗原发生交叉反应：这可能是眼病与自身免疫性甲状腺疾病相关联的一种机制。
Clin Exp Immunol. 1985 Nov;62(2):361-70.
4
[Immunological background of chronic liver diseases].[慢性肝病的免疫学背景]
Duodecim. 1971;87(22):1457-60.
5
Immunological factors in the evolution of active chronic hepatitis and other autoimmune liver diseases.活动性慢性肝炎及其他自身免疫性肝病演变过程中的免疫因素。
Clin Gastroenterol. 1975 May;4(2):297-313.
6
Demonstration of mitochondrial antibodies in sera from patients with chronic liver diseases reacting with two different types of complement-fixing antigens.慢性肝病患者血清中线粒体抗体与两种不同类型补体结合抗原发生反应的证明。
Minerva Gastroenterol. 1976 Jul-Sep;22(3):185-9.
7
Mitochondrial antibodies in chronic liver diseases and connective tissue disorders: further characterization of the autoantigens.慢性肝病和结缔组织疾病中的线粒体抗体：自身抗原的进一步特征分析
Clin Exp Immunol. 1980 Jul;41(1):43-54.
8
Serological studies of auto-antibodies in acute and chronic liver disease.急慢性肝病自身抗体的血清学研究。
Int Arch Allergy Appl Immunol. 1965;28(5):240-9. doi: 10.1159/000229667.
9
[Liver and the formation of humoral antibodies to foreign antigens. Hagedorn lecture 1973].[肝脏与针对外来抗原的体液抗体的形成。哈格多恩讲座，1973年]
Ugeskr Laeger. 1973 Jun 11;135(24):1233-8.
10
[Immunopathological phenomenona in liver diseases].[肝脏疾病中的免疫病理现象]
Z Gesamte Inn Med. 1975 Dec 1;30(23):258-61.
本文引用的文献
1
[Experiences with the collodion-precipitin reaction for the detection of auto-antibodies].[用于检测自身抗体的火棉胶沉淀反应的经验]
Klin Wochenschr. 1950 May 15;28(19-20):349-50. doi: 10.1007/BF01485957.
2
[On the demonstration of complement binding auto-antibodies in kidney and liver disease].[关于肾脏和肝脏疾病中补体结合自身抗体的证明]
Z Gesamte Exp Med. 1952 May 7;118(4):352-72.
3
[Collodium-precipitin reaction and erythrocyte agglutination reaction; comparative studies in proving organic autoantibodies].[火棉胶沉淀素反应与红细胞凝集反应；用于证实器官自身抗体的比较研究]
Klin Wochenschr. 1955 May 1;33(17-18):445-7. doi: 10.1007/BF01467989.
4
[Immunothrombopenia with acute course].[急性病程免疫性血小板减少症]
Wien Z Inn Med. 1954 Dec;35(12):493-8.
5
[AUTOIMMUNE PROCESSES AGAINST LIVER TISSUE].[针对肝脏组织的自身免疫过程]
Schweiz Med Wochenschr. 1964 Feb 15;94:257-62.
6
[IMMUNOLOGICAL PROBLEMS IN CHRONIC HEPATITIS AND LIVER CIRRHOSIS].[慢性肝炎和肝硬化中的免疫问题]
Dtsch Med Wochenschr. 1964 Apr 10;89:723-30. doi: 10.1055/s-0028-1111079.
7
SEROLOGICAL ABNORMALITIES IN PATIENTS WITH LIVER DISEASE.肝病患者的血清学异常
Br Med J. 1964 Mar 7;1(5383):592-4. doi: 10.1136/bmj.1.5383.592.
8
A THROMBOCYTE CONSUMPTION TEST FOR THE DEMONSTRATION OF AUTOANTIBODY-LIKE SERUM FACTORS.一种用于检测类自身抗体血清因子的血小板消耗试验。
J Clin Pathol. 1963 Sep;16(5):441-4. doi: 10.1136/jcp.16.5.441.
9
[Significance of antihuman globulin consumption test in infantile rheumatic fever].[抗人球蛋白消耗试验在小儿风湿热中的意义]
Orv Hetil. 1960 Oct 16;101:1481-4.
10
Occurrence of complement-fixing antibodies reactive with normal tissue constituents in normal and disease states.在正常和疾病状态下与正常组织成分发生反应的补体结合抗体的出现情况。
J Clin Invest. 1961 Mar;40(3):517-24. doi: 10.1172/JCI104279.
Zotero 插件