Alitalo I, Hietala A
Nord Vet Med. 1977 Nov;29(11):498-501.
Either atropine, isoprenaline, neostigmine or practolol was given intravenously in therapeutic doses to dogs anesthetized with pentobarbitone sodium. Cardiac arrhythmias were induced by potassium chloride intravenously as a bolus injection in a dose of 0.3 mmol/kg. The standard electrocardiographic lead II was recorded continuously. pH, Po2 and Pco2 were checked from arterial blood samples before and after the injection. The isoprenaline treated dogs showed the smallest amount of arrhythmias and all the dogs survived. More severe arrhythmias were seen in the neostigmine and practolol treated dogs and the most severe occurrences were encountered in the atropine treated dogs.
将治疗剂量的阿托品、异丙肾上腺素、新斯的明或心得宁静脉注射给用戊巴比妥钠麻醉的狗。通过静脉推注氯化钾（剂量为0.3 mmol/kg）诱发心律失常。连续记录标准心电图II导联。在注射前后从动脉血样本中检测pH值、氧分压和二氧化碳分压。接受异丙肾上腺素治疗的狗心律失常的发生率最低，所有狗均存活。新斯的明和心得宁治疗的狗出现更严重的心律失常，而阿托品治疗的狗心律失常最为严重。
