铍对磷酸葡萄糖变位酶的抑制作用。
The inhibition of phosphoglucomutase by beryllium.
作者信息
Aldridge W N, Thomas M
出版信息
Biochem J. 1966 Jan;98(1):100-4. doi: 10.1042/bj0980100.
Abstract
- The inhibition of phosphoglucomutase by beryllium has been examined. 2. Inhibition by beryllium does not occur unless a complex-forming agent such as cysteine or imidazole is present. It is therefore similar to activation by magnesium. 3. The inhibition is progressive and the rate follows first-order kinetics, which may be defined by a bimolecular rate constant. 4. In the presence of magnesium the rate of inhibition is less. By using a fixed time for inhibition competition between beryllium and magnesium may be demonstrated. After inhibition has taken place, the addition of magnesium does not reverse it.
摘要
- 已对铍对磷酸葡萄糖变位酶的抑制作用进行了研究。2. 除非存在诸如半胱氨酸或咪唑等能形成复合物的试剂，铍不会产生抑制作用。因此，这与镁的激活作用类似。3. 抑制作用是渐进性的，速率符合一级动力学，这可以由双分子速率常数来定义。4. 在有镁存在的情况下，抑制速率较小。通过设定固定的抑制时间，可以证明铍和镁之间存在竞争。抑制发生后，加入镁并不能使其逆转。
相似文献
1
The inhibition of phosphoglucomutase by beryllium.铍对磷酸葡萄糖变位酶的抑制作用。
Biochem J. 1966 Jan;98(1):100-4. doi: 10.1042/bj0980100.
2
Phosphoglucomutase. IV. Inactivation by beryllium ions.磷酸葡萄糖变位酶。IV. 被铍离子灭活
J Biol Chem. 1967 Apr 25;242(8):1671-9.
3
Activation and inhibition in the phosphoglucomutase system.磷酸葡萄糖变位酶系统中的激活与抑制作用。
J Biol Chem. 1966 Jun 10;241(11):2596-602.
4
The inhibition of enzymes by beryllium.铍对酶的抑制作用。
Biochem J. 1966 Jan;98(1):94-9. doi: 10.1042/bj0980094.
5
The addition and release of magnesium in the phosphoglucomutase reaction. I. Evidence for a random order of addition.
J Biol Chem. 1966 Jun 10;241(11):2603-10.
6
INHIBITION OF PHOSPHOGLUCOMUTASE BY ANIONS, PHOSPHATE ESTERS AND MG ION.阴离子、磷酸酯和镁离子对磷酸葡萄糖变位酶的抑制作用
Acta Physiol Acad Sci Hung. 1965;27:327-40.
7
The addition and release of magnesium in the phosphoglucomutase reaction. II. Kinetic control of alternative pathways.
J Biol Chem. 1966 Aug 10;241(15):3499-506.
8
Role of bivalent cations in the phosphoglucomutase system. V. The phosphoglucomutase-copper(II) complex.
Biochim Biophys Acta. 1970 Dec 22;221(3):522-8. doi: 10.1016/0005-2795(70)90223-0.
9
[Effect of beryllium and some other bivalent cations on the phosphoglucomutase activity of muscles].[铍及其他一些二价阳离子对肌肉磷酸葡萄糖变位酶活性的影响]
Vopr Med Khim. 1961 Nov-Dec;7:605-8.
10
[Fluorimetric study of methacycline complex formation with beryllium, aluminum, magnesium, calcium and zinc ions].
Antibiotiki. 1980 May;25(5):338-44.
引用本文的文献
1
Role of Liv-52 in protection against beryllium intoxication.利维-52在预防铍中毒中的作用。
Biol Trace Elem Res. 1994 Jun;41(3):201-15. doi: 10.1007/BF02917423.
2
Uptake, distribution and binding of beryllium to organelles of the rat liver cell.铍在大鼠肝细胞细胞器中的摄取、分布及结合
Biochem J. 1968 Feb;106(4):811-20. doi: 10.1042/bj1060811.
3
Effects of beryllium on deoxyribonucleic acid-synthesizing enzymes in regenerating rat liver.铍对再生大鼠肝脏中脱氧核糖核酸合成酶的影响。
Biochem J. 1970 Dec;120(3):623-34. doi: 10.1042/bj1200623.
4
Histochemical method for the demonstration of the activity of phosphoglucomutase.用于显示磷酸葡萄糖变位酶活性的组织化学方法。
Histochemie. 1967;8(3):248-51. doi: 10.1007/BF00306087.
本文引用的文献
1
Factors influencing the formation of Robison ester.影响罗宾逊酯形成的因素。
Biochem J. 1939 Aug;33(8):1241-4. doi: 10.1042/bj0331241.
2
Studies on the mechanism of acute beryllium poisoning.
J Pharmacol Exp Ther. 1951 Jul;102(3):165-78.
3
AFFINITY AND PHOSPHORYLATION CONSTANTS FOR THE INHIBITION OF ESTERASES BY ORGANOPHOSPHATES.有机磷酸酯对酯酶抑制作用的亲和力及磷酸化常数
Science. 1964 May 22;144(3621):992-3. doi: 10.1126/science.144.3621.992.
4
Time dependent activation of phospho-glucomutase by magnesium and imidazole.
Fed Proc. 1961 Sep;2:90-4.
5
Techniques for determining glutathione in animal tissues.测定动物组织中谷胱甘肽的技术。
Biochem Soc Symp. 1959;17:17-25.
6
Statistical estimations in enzyme kinetics.酶动力学中的统计估计
Biochem J. 1961 Aug;80(2):324-32. doi: 10.1042/bj0800324.
7
On the mechanism of activation of phosphoglucomutase by metal ions.关于金属离子激活磷酸葡萄糖变位酶的机制。
Biochem J. 1961 Jun;79(3):574-84. doi: 10.1042/bj0790574.
8
Amino-acid patterns in vitamin A-deficient rats.维生素A缺乏大鼠的氨基酸模式
Nature. 1961 Feb 25;189:660-1. doi: 10.1038/189660a0.
9
The determination of glutathione in blood and tissues.血液和组织中谷胱甘肽的测定。
Biochem J. 1955 Aug;60(4):696-702. doi: 10.1042/bj0600696.
10
The occurrence of a group transfer involving enzyme (phosphoglucomutase) and substrate.涉及酶（磷酸葡萄糖变位酶）和底物的基团转移的发生。
Science. 1954 May 7;119(3097):631-4. doi: 10.1126/science.119.3097.631.
Zotero 插件